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49ers vs. Rams Week 10 Recap: SF Falls 42-26 at Home; Mac Jones Throws 3 TDs in Shootout Loss

Shootout at Levi's: 49ers Fall to Rams in High-Scoring Battle

By 49ers Faithful Staff

The San Francisco 49ers couldn't keep pace with a high-powered Los Angeles attack, falling 42–26 to the Los Angeles Rams. Despite a 319-yard, 3-touchdown performance from Mac Jones, the short-handed Niners defense had no answer for Matthew Stafford as they dropped to 6-4 on the season.



🏈 NFL 2025 Season
Week 10 — November 9, 2025
Santa Clara, CA • Levi's Stadium
Final Score: Los Angeles Rams 42, San Francisco 49ers 26
Attendance: 71,239

TeamQ1Q2Q3Q4Final
Rams 14771442
49ers 0771226

49ers offense huddles during Week 10 vs Rams
A frustrating afternoon in Santa Clara as the Rams’ passing attack proved too much.


Game Summary

In a rematch of their Week 5 overtime thriller, the Rams jumped out to a 21–0 lead early in the second quarter. Mac Jones responded with three second-half touchdown drives, while George Kittle reached a major career milestone. Missed conversions and late Rams scores ultimately sealed the outcome.

Season Milestone: George Kittle recorded his 500th career reception, becoming just the third tight end in 49ers history to do so.

Key Player Performances

  • Mac Jones: 33/39, 319 yards, 3 TDs, 1 INT
  • George Kittle: 9 catches, 84 yards, 1 TD
  • Jauan Jennings: 6 catches, 71 yards, 1 TD
  • Brian Robinson Jr.: 8 carries, 41 yards, 1 TD
  • Tatum Bethune: 10 tackles


Turnover Battle

The 49ers finished -2 in the turnover margin, with both giveaways leading to Rams points.



Looking Ahead & Injury Update

The 49ers head to Arizona in Week 11.

  • Luke Farrell: Day-to-day with a stinger
  • Brock Purdy: Expected to compete for the starting role
  • Nick Bosa: Absence loomed large with no sacks recorded


LABELS

Mac Jones, CMC, Kittle, Jennings, Farrell, Robinson, Bethune, 49ers, rams, Santa Clara, week10, recap, loss, nfc west, home game



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