Desert Dominance: Purdy Returns, CMC Scores Thrice in Blowout Road Win
By 49ers Faithful Staff
The San Francisco 49ers welcomed back Brock Purdy in style, dismantling the Arizona Cardinals 41–22. From a 98-yard opening kickoff return to CMC’s three-touchdown performance, the Niners dominated every phase to secure a crucial road win and move to 7-4.
Week 11 — November 16, 2025
Glendale, AZ • State Farm Stadium
Final Score: San Francisco 49ers 41, Arizona Cardinals 22
Attendance: 65,122
| Team | Q1 | Q2 | Q3 | Q4 | Final |
|---|---|---|---|---|---|
| 49ers | 13 | 12 | 10 | 6 | 41 |
| Cardinals | 7 | 3 | 0 | 12 | 22 |
Game Summary
The 49ers struck immediately when Skyy Moore returned the opening kickoff 98 yards, setting up a first-play touchdown by CMC. Brock Purdy was sharp throughout, throwing three touchdowns and repeatedly exploiting mismatches with George Kittle. Defensively, San Francisco forced three takeaways, including a 64-yard interception return by Deommodore Lenoir and a goal-line fumble forced by Upton Stout.
Key Player Performances
- Brock Purdy: 19/26, 200 yards, 3 TDs, 0 INT — 133.5 passer rating
- CMC: 121 total yards, 3 TDs — Extended his NFL record streak
- George Kittle: 6 catches, 67 yards, 2 TDs — 50th career touchdown
- Skyy Moore: 98-yard kickoff return — Sparked the rout
- Deommodore Lenoir: 1 INT, 64-yard return
Turnover Battle
The 49ers dominated the turnover margin 3–1, completely disrupting Arizona’s offensive rhythm.
- Secondary Takeaways: Malik Mustapha and Deommodore Lenoir intercepted Jacoby Brissett.
- Goal-Line Stand: Rookie Upton Stout forced a fumble at the 1-yard line, recovered by Keion White.
Looking Ahead & Injury Update
The 49ers return home for a Monday Night Football matchup against the Panthers.
- Tatum Bethune: High ankle sprain, expected to miss multiple weeks
- Eddy Piñeiro: Strained hamstring; kicker tryouts expected
- Ricky Pearsall: Returned in Arizona, finished with one catch
LABELS
Purdy, CMC, Kittle, Moore, Lenoir, Mustapha, Stout, 49ers, cardinals, Arizona, week11, recap, win, TD, nfc west, road win
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