MNF Masterclass: Purdy’s 5 Touchdowns Power 49ers Past Colts in Indy
The San Francisco 49ers put the league on notice with a dominant 48–27 road win over the Indianapolis Colts on Monday Night Football. Brock Purdy delivered a career-best performance with five touchdown passes, while Christian McCaffrey and George Kittle carved up the Colts' defense to secure the Niners' fifth straight victory.
Week 16 — December 22, 2025
Indianapolis, IN • Lucas Oil Stadium
Final Score: San Francisco 49ers 48, Indianapolis Colts 27
Attendance: 66,340
| Team | Q1 | Q2 | Q3 | Q4 | Final |
|---|---|---|---|---|---|
| 49ers | 14 | 10 | 10 | 14 | 48 |
| Colts | 7 | 10 | 3 | 7 | 27 |
|
| History in Indy: Brock Purdy set a new career high with five touchdown passes to keep the Niners in the race for the NFC's top seed. |
Game Summary
In a high-stakes primetime matchup, Brock Purdy silenced the crowd at Lucas Oil Stadium by orchestrating a nearly flawless offensive performance. Purdy spread the ball around brilliantly, connecting with Christian McCaffrey for two receiving scores and finding George Kittle, Jauan Jennings, and Demarcus Robinson for one each. While the Colts stayed competitive through the first half, the 49ers pullled away in the fourth quarter. Christian McCaffrey topped 100 yards rushing for the first time in three weeks, providing the balance needed to keep the defense honest. The exclamation point came late in the fourth when Dee Winters intercepted Philip Rivers and returned it 74 yards for a pick-six.
Key Player Performances
- Brock Purdy: 25/34, 295 yards, 5 TDs, 1 INT — Career-high touchdown total
- Christian McCaffrey: 21 carries, 117 yards; 6 catches, 29 yards, 2 receiving TDs — 146 total yards
- George Kittle: 7 catches, 115 yards, 1 TD — Dominated the middle of the field
- Jauan Jennings: 5 catches, 71 yards, 1 TD — A physical presence in the red zone
- Dee Winters: 4 tackles, 1 INT (74-yard TD return) — Sealed the game in the fourth quarter
- Ji'Ayir Brown: 9 tackles, 1 TFL — Led the team in tackles for the night
Turnover Battle
The 49ers defense capitalized on late-game desperation, turning a tight contest into a blowout.
- Pick-Six: Dee Winters jumped a Philip Rivers pass and took it 74 yards to the house to ice the victory.
- Special Teams Spark: Jake Tonges recovered a muffed kickoff return by the Colts, leading to an early 49ers touchdown.
Looking Ahead & Injury Update
The 49ers travel to the Windy City for a Week 17 clash with the Chicago Bears.
- Kendrick Bourne: Surpassed 500 receiving yards on the season, triggering a $500,000 contract incentive.
- Dee Winters: His breakout game included the pick-six and two pass breakups.
- Playoff Picture: At 11-4, the 49ers are still in the hunt for the NFC's #1 overall seed.
LABELS
Purdy, Christian McCaffrey, Kittle, Jennings, Robinson, Winters, Brown, Tonges, 49ers, colts, Indianapolis, week16, highlight, recap, win, TD, nfc west, road win, mnf
🔴 Purdy for MVP?
That was a statement win on national TV! Does Brock Purdy have your vote for MVP? Join the conversation and write for the 49ers Faithful as we head toward the postseason!
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