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49ers vs. Panthers Week 12 Recap: SF Wins 20-9 on MNF; CMC Totals 142 Yards in Reunion Game

Primetime Power: CMC and Defense Carry Niners Past Panthers on MNF

By 49ers Faithful Staff

The San Francisco 49ers relied on a dominant ground game and a ball-hawking secondary to defeat the Carolina Panthers 20–9 on Monday Night Football. CMC reminded his former team of his superstar status with 142 scrimmage yards, while the defense forced multiple turnovers to move the Niners to 8-4.


🏈 NFL 2025 Season
Week 12 — November 24, 2025
Santa Clara, CA • Levi’s Stadium
Final Score: San Francisco 49ers 20, Carolina Panthers 9
Attendance: 71,337

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Christian McCaffrey celebrates during the Week 12 MNF win
Reunion Game: Christian McCaffrey totaled 142 yards and a touchdown against his former team.

Game Summary

The 49ers opened with a 15-play touchdown drive capped by a Jauan Jennings score. Despite three early interceptions by Brock Purdy, Kyle Shanahan leaned on the run game in the second half. The defense delivered, led by Ji'Ayir Brown, whose two interceptions sealed the victory.

NFC Honors: Ji'Ayir Brown was named NFC Defensive Player of the Week.

Key Player Performances

  • CMC: 142 total yards, 1 TD
  • Ji'Ayir Brown: 2 INTs
  • Jauan Jennings: TD reception
  • George Kittle: 78 receiving yards

Looking Ahead

The 49ers travel to Cleveland for a Week 13 matchup with the Browns.


LABELS

Purdy, CMC, Jennings, Kittle, Brown, 49ers, Panthers, week12, recap, MNF, win


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